Tau Protein in Frontotemporal Dementia Linked to Chromosome 3 (FTD-3)
نویسندگان
چکیده
منابع مشابه
Chromosome 3 linked frontotemporal dementia (FTD-3).
BACKGROUND The authors have identified and studied a large kindred in which frontotemporal dementia (FTD) is inherited as an autosomal dominant trait. The trait has been mapped to the pericentromeric region of chromosome 3. METHODS The authors report on the clinical, neuroimaging, neuropsychological, and pathologic features in this unique pedigree collected during 17 years of study. RESULTS...
متن کاملTau protein in frontotemporal dementia linked to chromosome 3 (FTD-3).
Recent work on frontotemporal dementia (FTD) has revealed the existence of at least 3 genetically distinct groups of inherited FTD: FTDP-17, FTD and motor neuron disease linked to chromosome 9, and FTD linked to chromosome 3 (FTD-3). Tau, on chromosome 17, is the only gene where mutations have been identified and its involvement in FTD has been firmly established. The genes on chromosome 9 and ...
متن کاملFrontotemporal dementia linked to chromosome 3.
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
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Arnold Pick’s description of lobar atrophy with progressive aphasia, apraxia and behavioural disturbance has been renamed Frontotemporal Dementia (FTD). A significant expansion of knowledge has occurred in the last few years, especially in the molecular biology of FTD, which is estimated to account for 12-15% of all dementias and 30-50% of early onset cases. The clinical picture consists mainly...
متن کاملA reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.
A large Danish family has previously been reported in which autosomal dominant frontotemporal dementia (FTD) is genetically linked to chromosome 3 (FTD-3). A mutation was recently identified in the CHMP2B gene that is probably responsible for causing disease in this family. Because of its neuropathologic findings, FTD-3 was originally categorized as a subtype of frontotemporal lobar degeneratio...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2003
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/62.8.878